Randolph Roberts and HaeChul Park

We investigate the mechanisms that maintain and specify rapidly proliferating neural precursors during early embryogenesis and slowly proliferating radial glia in juvenile and adult fish. We are particularly interested in one discrete population of spinal cord radial glia marked by EGFP expression in Tg(olig2:egfp) transgenic lines. These cells appear to divide asymmetrically to produce one new radial glial cell and one new oligodendrocyte throughout adulthood and, thus, might serve as a good model for adult neural stem cells.