Publications

Vaught, D, WB Fang, J Mazerik, J Chen and DM Brantley-Sieders (2009) Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase. Mol Biol Cell (in revision).


Brantley-Sieders, DM, G. Zhuang, D. Vaught, T. Freeman, Y. Hwang, D. Hicks, and J. Chen (2009) Host-deficiency in Vav 2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo. Mol. Cancer Res (in press)


Brantley-Sieders, DM, Zhuang, G, Hicks, D, Fang, WB, Hwang, Y, Cates, JM, Coffman, K, Jackson, D, Bruckheimer, E, Muraoka-Cook, RS, Chen, J. (2008) The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest, 118(1): 64-78.

Bogan, C. J. Chen, R.T. Cormier (2008) Loss of EphA2 receptor tyrosine kinase reduces Apc^Min/+ tumorigenesis. Int. J. Cancer (in press).

J. Chen, G. Zhuang, L. Frieden, and W. Debinski (2008) Ephrins and Ephs in Cancer: Common Themes and Controversies.  Cancer Research 68(24):10031-3.

D. Vaught, D. Brantley-Sieders, and J. Chen (2008) Eph receptors in breast cancer: roles in tumor promotion and tumor suppression. Breast cancer research 10: 217

Fang, WB, Brantley-Sieders, DM, Hwang, Y, Ham, A, Chen, J. (2008) Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase. J Biol Chem, 283: 16017-16026.

Fang, WB, Ireton, RC, Zhuang, G, Takahashi, T, Reynolds, A, Chen, J. (2008) Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism. J Cell Sci, 121(Pt 3): 358-68.

Zhuang, G, Hunter, S, Hwang, Y, Chen, J. (2007) Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation. J Biol Chem, 282(4): 2683-94.

Brantley-Sieders, DM, Fang, WB, Hwang, Y, Hicks, D, Chen, J. (2006) Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice. Cancer Res, 66(21): 10315-24.

Brissova, M, Shostak, A, Shiota, M, Wiebe, PO, Poffenberger, G, Kantz, J, Chen, Z, Carr, C, Jerome, WG, Chen, J, Baldwin, HS, Nicholson, W, Bader, DM, Jetton, T, Gannon, M, Powers, AC. (2006) Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes, 55(11): 2974-85.

Chen, J, Hicks, D, Brantley-Sieders, D, Cheng, N, McCollum, GW, Qi-Werdich, X, Penn, J. (2006) Inhibition of retinal neovascularization by soluble EphA2 receptor. Exp Eye Res, 82(4): 664-673.

Hunter, SG, Zhuang, G, Brantley-Sieders, D, Swat, W, Cowan, CW, Chen, J. (2006) Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Mol Cell Biol, 26(13): 4830-42.

Brantley-Sieders, DM, Fang, WB, Hicks, DJ, Zhuang, G, Shyr, Y, Chen, J. (2005) Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. FASEB J, 19(13): 1884-6.

Fang, WB, Brantley-Sieders, DM, Parker, MA, Reith, AD, Chen, J. (2005) A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene, 24: 7859-68.

Ireton, RC, Chen, J. (2005) EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics. Curr Cancer Drug Targets, 5(3): 149-57.

Brantley-Sieders, D, Parker, M, Chen, J. (2004) Eph receptor tyrosine kinases in tumor and tumor microenvironment. Curr Pharm Des, 10(27): 3431-42.

Brantley-Sieders, D, Caughron, J, Hicks, D, Pozzi, A, Ruiz, J, Chen, J. (2004) EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci, 117(Pt 10): 2037-49.

Brantley-Sieders, D, Chen, J. (2004) Eph receptor tyrosine kinases in angiogenesis: from development to disease. Angiogenesis, 7(1): 17-28.

Parker, M, Roberts, R, Enriquez, M, Zhao, X, Takahashi, T, Cerretti, D, Daniel, T, Chen, J. (2004) Reverse endocytosis of transmembrane ephrin-B ligands via a clathrin-mediated pathway. Biochem Biophys Res Commun, 323(1): 17-23.

Cheng, N, Brantley, D, Fang, W, Liu, H, Fanslow, W, Cerretti, D, Bussell, K, Reith, A, Jackson, D, Chen, J. (2003) Inhibition of VEGF-dependent multistage carcinogenesis by soluble EphA receptors. Neoplasia, 5(5): 445-56.

Brantley, D, Cheng, N, Thompson, E, Lin, Q, Brekken, R, Thorpe, P, Muraoka, R, Cerretti, D, Pozzi, A, Jackson, D, Lin, C, Chen, J. (2002) Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene, 21(46): 7011-26.

Cheng, Nikki, Brantley, Dana M, Chen, Jin. (2002) The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev, 13(1): 75-85.

Cheng, N, Brantley, D, Liu, H, Lin, Q, Enriquez, M, Gale, N, Yancopoulos, G, Cerretti, D, Daniel, T, Chen, J. (2002) Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol Cancer Res, 1(1): 2-11.

Huynh-Do, U, Vindis, C, Liu, H, Cerretti, D, McGrew, J T, Enriquez, M, Chen, J, Daniel, T. (2002) Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis. J Cell Sci, 115(Pt 15): 3073-81.

Muraoka, R, Dumont, N, Ritter, C, Dugger, T, Brantley, D, Chen, J, Easterly, E, Roebuck, L R, Ryan, S, Gotwals, P, Koteliansky, V, Arteaga, C. (2002) Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest, 109(12): 1551-9.

Cheng, N, Chen, J. (2001) Tumor necrosis factor-alpha induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism. J Biol Chem, 276(17): 13771-7.

Chen, J, Ruley, H E. (1998) An enhancer element in the EphA2 (Eck) gene sufficient for rhombomere-specific expression is activated by HOXA1 and HOXB1 homeobox proteins. J Biol Chem, 273(38): 24670-5.

Chen, J, Nachabah, A, Scherer, C, Ganju, P, Reith, A, Bronson, R, Ruley, H E. (1996) Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion. Oncogene, 12(5): 979-88.