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UID:http://sitemason.vanderbilt.edu/element/bzrandu/id/66738
SUMMARY:Department of Psychology Neuroscience Seminar (Brown Bag)
DESCRIPTION:  Toru Takahata\, PhD\nVanderbilt University\nDepartment of Psychology/Kaas Lab\n      “Novel anatomical compartments within ocular dominance columns in macaque V1\: infragranular blobs and layer 4C border strips”\n    Since pioneer studies by Hubel and Wiesel in the mid 20th century\, the anatomical architecture and functional compartments of the visual system in the brain have been well studied. In Old World primates and apes\, visual afferents from the two eyes have segregated inputs into the granular layer (layer 4C)\, forming “ocular dominance columns (ODCs)” perpendicular to the pial surface. In addition\, the enzymatic reactivity of cytochrome oxidase (CO) reveals a “blob” structure within ODCs in supragranular layers (layers 2-4B)\, which has been characterized as a non-oriented\, color processing domain. In the present study\, I propose that the blob structure extends to infragranular layers (layers 5/6) and that there is “border strip” structure in the vicinity of boundaries of ODCs\, which have not been clearly defined previously. These compartments are revealed by the activity-dependent mRNA expression of immediate-early genes (IEGs)\, zif268 and c-fos\, after brief monocular deprivation (MD). After the brief (1-3 h) phase of MD by tetrodotoxin injection\, IEG mRNA expressions were patchy in infragranular layers\, as well as in supragranular layers\, and corresponded with CO blobs. In addition\, the IEG expressions in layer 4C were especially high in narrow zones along boundaries of ODCs. In later (> 5 h) phases\, the appearance of these structures was unclear\, as the IEG mRNA expression level became low throughout the deprived columns and high throughout the nondeprived columns. In cases of brief monocular eyelid suture\, changes of zif268 and c-fos expressions were not evident in layer 4C\, but the patchy pattern of the expression was obvious in infragranular layers\, which corresponded with CO blobs in supragranular layers. These changes of IEG mRNA expression provide new insights into anatomical architecture of primate V1\, and reveal how neuronal activity changes after acute disruption of binocular vision.\nDepartment of Psychology NEUROSCIENCE SEMINAR SERIES\nFor additional information\, contact Carol Wiley@ carol.wiley@vanderbilt.edu [javascript\:location.href='mailto\:'+String.fromCharCode(99\,97\,114\,111\,108\,46\,119\,105\,108\,101\,121\,64\,118\,97\,110\,100\,101\,114\,98\,105\,108\,116\,46\,101\,100\,117)+'?']\n
URL;VALUE=URI:http://www.vanderbilt.edu/psychological_sciences/
LOCATION:Wilson Hall\, room 316
CATEGORIES:academics,cas,colloquiumslecturesmeetingssymposiums,conferencesmeetingsseminarstrainingworkshops,vumc
CLASS:PUBLIC
SEQUENCE:10
DTSTAMP:20120210T095717
CREATED;TZID=US-Central:20081027T154852
LAST-MODIFIED;TZID=US-Central:20090519T152956
ORGANIZER;CN=Carol Wiley:MAILTO:carol.wiley@vanderbilt.edu
DTSTART;TZID=US-Central:20090129T121000
DTEND;TZID=US-Central:20090129T131000
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