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LAST-MODIFIED:19870101T000000Z
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DTSTART:16011104T020000
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UID:http://sitemason.vanderbilt.edu/element/bzrandu/id/62797
SUMMARY:The Department of Microbiology & Immunology Research in Progress Seminar Series\: Tynetta C. Fletcher
DESCRIPTION:Tynetta C. Fletcher\, Graduate Student\nMeharry Medical College\nFrom the laboratory of Dr. Jacek Hawiger\n"The Expression\, Turnover\, and Reconstitution of SOCS-3 During Endotoxin-Induced Septic Shock"\nSeptic Shock Syndrome\, an acute systemic inflammatory disorder caused by Gram- negative and Gram-positive bacteria\, is characterized by unregulated cytokine production\, multi-organ damage and vascular collapse.  By using a model of endotoxic lipopolysaccharide (LPS)-induced Septic Shock\, we were able to counteract the lethal effects of LPS with a novel intracellular protein therapy (IPT) based on a cell-penetrating form of Suppressor of Cytokine Signaling-3 (CP-SOCS3). SOCS3 is a known physiologic inhibitor of the JAK/STAT pathway as well as LPS-activated IRAK1/TRAF6 and TRIF/TRAF3 pathways.  An unanticipated benefit of using CP-SOCS3 in vivo is its persistence in blood leukocytes/lymphocytes and spleen cells\, suggesting different intracellular kinetics for this bioengineered protein.  Comparative analysis of endogenous and cell-penetrating forms of SOCS3 turnover allows us to elucidate the mechanism of its persistence and to develop CP-SOCS3 variants that would offer more effective IPT against LPS-induced lethal shock.\n
URL;VALUE=URI:http://www.mc.vanderbilt.edu/microbiology/
LOCATION:Medical Center North (MCN)\, room A5305 
CATEGORIES:conferencesmeetingsseminarstrainingworkshops,vumc
CLASS:PUBLIC
SEQUENCE:3
DTSTAMP:20120210T082311
CREATED;TZID=US-Central:20080815T111615
LAST-MODIFIED;TZID=US-Central:20081031T113215
ORGANIZER;CN=Jean Tidwell:MAILTO:jean.tidwell@vanderbilt.edu
DTSTART;TZID=US-Central:20080821T093000
DTEND;TZID=US-Central:20080821T103000
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